Human Diabetic Primary Kidney Vein Fibroblast Cells
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Product Overview
Description
Human Diabetic Primary Kidney Vein Fibroblast Cells are specialized cells derived from the kidney's venous tissue of individuals with diabetes. These fibroblasts play a crucial role in the kidney's structural integrity and function, as they contribute to the extracellular matrix and support the surrounding tissues.
Guarantee expansion for a minimum of 2-5 population
doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBPDF009
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Cell Characteristics
Primary Cells: These are isolated directly from human tissue (kidney vein) and have not been immortalized. They have a finite lifespan and closely mimic the in vivo physiological state.
Diabetic Origin: The donor has a confirmed diagnosis of diabetes mellitus (often Type II). These cells retain the epigenetic and metabolic memory of the diabetic state (e.g., increased basal expression of inflammatory cytokines, altered glucose metabolism).
Anatomical Location: The renal vein is the vessel that carries filtered blood away from the kidney. Fibroblasts from this site are crucial for studying vascular fibrosis and the structural changes in the kidney's vascular outflow tract under hyperglycemic conditions.
Quick Facts
Product Type
Human Type II Diabetes Endothelial Cells
Viability
>95% viable (Trypan Blue exclusion)
Applications
Diabetic Nephropathy: Investigating the mechanism…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
Diabetic Nephropathy: Investigating the mechanisms of renal fibrosis
Suitable for diabetic nephropathy: investigating the mechanisms of renal fibrosis studies and research applications
extracellular matrix (ECM) accumulation (Collagen I
Suitable for extracellular matrix (ecm) accumulation (collagen i studies and research applications
Fibronectin)
Suitable for fibronectin) studies and research applications
and the epithelial-mesenchymal transition (EMT) signaling pathways. Inflammation: Examining the role of hyperglycemia in activating NF-B and releasing IL-6
Suitable for and the epithelial-mesenchymal transition (emt) signaling pathways. inflammation: examining the role of hyperglycemia in activating nf-b and releasing il-6 studies and research applications
TNF-
Suitable for tnf- studies and research applications
and MCP-1. Drug Screening: Testing anti-fibrotic agents (e.g.
Suitable for and mcp-1. drug screening: testing anti-fibrotic agents (e.g. studies and research applications
SGLT2 inhibitors
Suitable for sglt2 inhibitors studies and research applications
GLP-1 analogs
Suitable for glp-1 analogs studies and research applications
or TGF- inhibitors) in a cell type directly relevant to diabetic complications. Vascular Remodeling: Understanding how high glucose environments affect the structural integrity of the renal venous system.
Suitable for or tgf- inhibitors) in a cell type directly relevant to diabetic complications. vascular remodeling: understanding how high glucose environments affect the structural integrity of the renal venous system. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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