Human Diabetic Primary Lung Fibroblast Cells
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Product Overview
Description
Human Diabetic Primary Lung Fibroblast Cells are specialized connective tissue cells that originate from lung tissue harvested from individuals diagnosed with diabetes. These cells are part of the body's intricate network of fibroblasts, which play essential roles in maintaining the structural integrity of the lungs and facilitating various physiological processes.
Guarantee expansion for a minimum of 2-5 population
doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBPDF013
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Characterization Markers
- Characterized by spindle morphology under light microscopy.
- Negative for von Willebrand Factor (vWF) , Cytokeratin 18,
and alpha-smooth muscle actin .
- Isolated and characterized to ensure fibroblast purity and identity.
Quick Facts
Product Type
Human Type II Diabetes Endothelial Cells
Viability
>95% viable (Trypan Blue exclusion)
Applications
A. Diabetic Lung Disease (Diabetic Pneumopathy) …
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
A. Diabetic Lung Disease (Diabetic Pneumopathy) Researchers use these cells to understand why Type 2 diabetics have an increased risk of developing idiopathic pulmonary fibrosis (IPF) and why diabetics have worse outcomes in Acute Respiratory Distress Syndrome (ARDS) and COVID-19. B. Wound Healing & Repair Diabetes impairs wound healing. In the lung
Suitable for a. diabetic lung disease (diabetic pneumopathy) researchers use these cells to understand why type 2 diabetics have an increased risk of developing idiopathic pulmonary fibrosis (ipf) and why diabetics have worse outcomes in acute respiratory distress syndrome (ards) and covid-19. b. wound healing & repair diabetes impairs wound healing. in the lung studies and research applications
this translates to abnormal repair following injury. These cells are used to study: Impaired migration (chemotaxis). Dysregulated proliferation. Matrix metalloproteinase (MMP) / Tissue inhibitor of metalloproteinase (TIMP) imbalance (leading to either excessive degradation or excessive scarring). C. Drug Discovery & Toxicology These cells serve as a "diseased model" for screening: Anti-fibrotics: Testing drugs like Pirfenidone or Nintedanib on diabetic fibroblasts to see if efficacy differs from non-diabetic cells. Senolytics: Since diabetes accelerates cellular senescence
Suitable for this translates to abnormal repair following injury. these cells are used to study: impaired migration (chemotaxis). dysregulated proliferation. matrix metalloproteinase (mmp) / tissue inhibitor of metalloproteinase (timp) imbalance (leading to either excessive degradation or excessive scarring). c. drug discovery & toxicology these cells serve as a "diseased model" for screening: anti-fibrotics: testing drugs like pirfenidone or nintedanib on diabetic fibroblasts to see if efficacy differs from non-diabetic cells. senolytics: since diabetes accelerates cellular senescence studies and research applications
these cells are used to test drugs that clear senescent cells (e.g.
Suitable for these cells are used to test drugs that clear senescent cells (e.g. studies and research applications
Dasatinib + Quercetin) to improve lung function.
Suitable for dasatinib + quercetin) to improve lung function. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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