Human Tonsil Microvascular Endothelial Cells
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Product Overview
Description
Human Tonsil Microvascular Endothelial Cells (HTMECs) are a specialized population of primary endothelial cells derived from the intricate microvasculature of the human palatine tonsils.
Endothelial cells, in general, form the innermost cellular lining of all blood and lymphatic vessels throughout the body, acting as a dynamic interface between circulating blood or lymph and the surrounding tissues. In the context of the tonsil, these microvascular endothelial cells play a particularly critical role not only in maintaining vascular integrity and regulating fluid exchange, but also in orchestrating immune surveillance and lymphocyte trafficking within one of the body’s most immunologically active tissues.
Guarantee expansion for a minimum of 2-5 population doublings.
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Key Features
Catalog Number: NBP-0013
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
CELL MARKERS
HTECs are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and/or CD31 (PECAM1) two of the most definitive endothelial cell markers.
Several endothelial-specific transcripts have been identified in tonsil HECs, including those encoding E-selectin, vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial-junctional adhesion molecule, and platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31).
HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing the endothelium.
HEV cuboidal endothelial cells express the adhesion molecules GlyCAM-1, ICAM-1, and CD34. They also secrete the chemokine CCL21.
The interfollicular space of the tonsil encompasses blood and lymphatic vessels composed of CD31+ blood endothelial cells (BECs) and PDPN+CD31+ lymphatic endothelial cells (LECs), respectively.
Quick Facts
Product Type
Human Endothelial Cells
Viability
>98% viable (Trypan Blue exclusion)
Applications
-Inflammation modeling: Morphological and physiol…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
-Inflammation modeling: Morphological and physiological changes in human tonsil endothelial cells can lead to the development of tonsillitis. Human Tonsil Endothelial Cells are a useful model for studying inflammation in the tonsils and are also useful tools to establish in vitro disease models for High Throughput and High Content Screening. -Tissue engineering: Endothelial cells also have important applications in tissue engineering studies
Suitable for -inflammation modeling: morphological and physiological changes in human tonsil endothelial cells can lead to the development of tonsillitis. human tonsil endothelial cells are a useful model for studying inflammation in the tonsils and are also useful tools to establish in vitro disease models for high throughput and high content screening. -tissue engineering: endothelial cells also have important applications in tissue engineering studies studies and research applications
especially in the development of artificial vascular grafts as alternatives to donor-sourced grafts or for supporting organ or tissue engineering with a vascular network.
Suitable for especially in the development of artificial vascular grafts as alternatives to donor-sourced grafts or for supporting organ or tissue engineering with a vascular network. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
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