Human Prostate Microvascular Endothelial Cells
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Product Overview
Description
Human Prostate Microvascular Endothelial Cells (HPrMEC) are isolated from healthy human prostate tissue. They are initiated by the elutriation of dispase-dissociated normal prostate tissue. Human Prostate Microvascular Endothelial Cells (HPrMECs) are far more than passive structural components of prostate blood vessels.
They are active biological participants in prostate growth and cancer progression. Through the secretion of cytokines like IL-6, growth factors like VEGF, and chemokines like CCL5, they communicate with neighboring prostate cells to regulate tissue homeostasis and, in disease states, to actively drive tumor invasion and metastasis. Their unique tissue-specific properties make them indispensable tools in prostate cancer research and the development of new therapeutic strategies.
Guarantee expansion for a minimum of 2-5 population doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBP-0014
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
CELL CHARACTERISTICS
The cells exhibit a cobblestone-like morphology with dark nuclei, and express CD31 and/or VE-Cadherin endothelial cell markers. They are positive for von Willebrand factor, CD31, CD62E (after stimulation with TNF-alpha), and alpha-actin, and proliferation is stimulated by vascular endothelial growth factor (VEGF).
Quick Facts
Product Type
Human Endothelial Cells
Viability
>98% viable (Trypan Blue exclusion)
Applications
Human Prostate Microvascular Endothelial Cells pr…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
Human Prostate Microvascular Endothelial Cells provide an in vitro model in the pathophysiological studies of prostatic diseases
Suitable for human prostate microvascular endothelial cells provide an in vitro model in the pathophysiological studies of prostatic diseases studies and research applications
such as prostatitis
Suitable for such as prostatitis studies and research applications
prostatic hyperplasia
Suitable for prostatic hyperplasia studies and research applications
or prostate cancer.
Suitable for or prostate cancer. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
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