Human Induced Pluripotent Stem Cells-Derived Schwann
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Product Overview
Description
Human iPSC-derived Schwann cells are specialized glial cells found in the peripheral nervous system, developed from human induced pluripotent stem cells through a process of differentiation that involves neural crest and Schwann cell lineages. These remarkable cells are designed to closely replicate the biological functions of human Schwann cells, which play essential roles in supporting axonal health, facilitating myelination, promoting nerve repair signaling, and elucidating the complex mechanisms associated with peripheral neuropathy.
Acting as a renewable and versatile source, these Schwann cells provide a human-origin platform that is invaluable for modeling various diseases, discovering new drugs, and advancing research in the field of regenerative medicine. Researchers often confirm the identity of these Schwann cells through specific markers, including SOX10, S100?, GFAP, and p75NGFR/NGFR. Additionally, they utilize mature myelination-associated markers, such as MPZ/P0, along with other related Schwann cell genes, to ensure accurate characterization of these vital cells.
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Key Features
Catalog Number: NBP-0500-002-IPC
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Characteristics:
Human iPSC-derived Schwann cells typically exhibit an elongated, spindle-like, or bipolar shape, which resembles that of native Schwann cells. They express specific markers associated with the Schwann cell lineage, including SOX10, S100, p75NGFR, GFAP, and MPZ/P0.
Additionally, these cells may demonstrate functional capabilities, such as interacting with neurons, supporting axonal growth, and engaging in activities related to myelination when cultured under appropriate conditions. Since they are derived from induced pluripotent stem cells (iPSCs), these Schwann cells can be produced from healthy donors or tailored to patient-specific genetic backgrounds, making them valuable for creating reproducible models of human diseases.
Quick Facts
Product Type
Stem Cells
Viability
>95% viable (Trypan Blue exclusion)
Applications
Research & Development
Availability
In Stock • Global Shipping
Technical Specifications
Applications & Use Cases
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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