Human Internal Mammary Artery Endothelial Cells
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Product Overview
Description
Primary Endothelial Cells are specialized cells derived from the internal mammary artery of humans. These cells constitute the inner cellular lining of the artery, forming a crucial barrier between the bloodstream and surrounding tissues. They play a vital role in several fundamental processes in vascular biology, including the regulation of blood flow, which is essential for maintaining proper circulation and oxygen delivery throughout the body.
Endothelial cells also contribute to barrier function by controlling the permeability of the blood vessel wall. This means they help determine what substances can pass from the bloodstream into the tissues, thereby regulating inflammation and immune responses. Additionally, these cells are instrumental in angiogenesis, the process through which new blood vessels are formed from existing ones. This is particularly important during wound healing and tissue repair, as well as in the formation of new blood vessels in response to various physiological demands. Their ability to secrete various signaling molecules further underscores their importance in maintaining cardiovascular health and responding to injury.
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Key Features
Catalog Number: NBP-0018
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
CELLS CHARACTERIZATION
-Cobblestone morphology in culture.
-Express endothelial markers (e.g., CD31, vWF, VE-cadherin).
-Exhibit tight junctions and tube formation ability.
-Responsive to vasoactive substances.
-Maintain functional nitric oxide synthesis.
-Low immunogenicity compared to other vascular sources.
Quick Facts
Product Type
Human Endothelial cells
Viability
>98% viable (Trypan Blue exclusion)
Applications
-Vascular research (atherosclerosis, angiogenesis…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
-Vascular research (atherosclerosis
Suitable for -vascular research (atherosclerosis studies and research applications
angiogenesis
Suitable for angiogenesis studies and research applications
thrombosis). -Cardiovascular disease modeling. -Studies on endothelial function and dysfunction. -Drug screening for vascular therapies. -Graft and vascular tissue engineering. -Research on coronary artery bypass grafts (CABG)
Suitable for thrombosis). -cardiovascular disease modeling. -studies on endothelial function and dysfunction. -drug screening for vascular therapies. -graft and vascular tissue engineering. -research on coronary artery bypass grafts (cabg) studies and research applications
as the internal mammary artery is commonly used in bypass surgeries.
Suitable for as the internal mammary artery is commonly used in bypass surgeries. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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