Human Dermal Keratinocytes
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Product Overview
Description
Human Dermal Keratinocytes are specialized epithelial cells that are primarily derived from human skin. These vital cells represent the predominant cell type in the epidermis, the outermost layer of the skin.
They play a crucial role in establishing and maintaining the skin barrier, which protects the body from environmental hazards, such as pathogens and pollutants. Additionally, keratinocytes are essential for wound healing, as they actively participate in the repair process following skin injuries.
These cells originate in the basal layer of the epidermis, where they proliferate and gradually differentiate as they migrate toward the skin's surface. This journey not only changes their structure and function but also helps replenish the skin's outer layer, ensuring that it remains resilient and effective in safeguarding the body. Through these processes, keratinocytes significantly contribute to overall skin health and integrity.
Guarantee expansion for a minimum of 2-5 population doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBP-001-DK
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Characteristics:
-Polygonal, epithelial-like morphology in culture
-Express keratinocyte markers such as KRT5, KRT14, KRT1, KRT10, p63, and involucrin
-Capable of proliferation and differentiation under appropriate culture conditions
-Important for epidermal barrier formation and skin tissue organization
-Useful in 2D monolayer culture and 3D skin-equivalent models
Quick Facts
Product Type
Primary keratinocytes
Viability
>98% viable (Trypan Blue exclusion)
Applications
-Skin biology and epidermal differentiation studi…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
-Skin biology and epidermal differentiation studies -Wound healing and tissue repair research -Skin irritation
Suitable for -skin biology and epidermal differentiation studies -wound healing and tissue repair research -skin irritation studies and research applications
toxicity
Suitable for toxicity studies and research applications
and cosmetic testing -Inflammatory skin disease models -Psoriasis
Suitable for and cosmetic testing -inflammatory skin disease models -psoriasis studies and research applications
dermatitis
Suitable for dermatitis studies and research applications
and barrier-function studies -3D skin equivalent and organotypic culture models
Suitable for and barrier-function studies -3d skin equivalent and organotypic culture models studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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