SV40-Human Pulmonary Microvascular Endothelial Cells
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Product Overview
Description
SV40-HPuMVECs are genetically modified cell lines created to address the limitations associated with the short lifespan of primary pulmonary microvascular endothelial cells. These engineered cells provide a reliable and consistent in vitro model, which researchers use to explore various aspects of lung microvascular biology. They are particularly valuable for studying mechanisms related to vascular permeability and the dysfunction of endothelial cells, offering insights that are crucial for understanding pulmonary health and disease.
Guarantee expansion for a minimum of 2-5 population
doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBP -0032SV40
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Characteristics
-Origin: Human pulmonary microvascular endothelium
-Immortalization method: SV40 large T antigen
-Morphology: Cobblestone-like endothelial monolayer
-Markers expressed:
CD31 (PECAM-1)
VE-cadherin (CD144)
vWF (von Willebrand factor)
-Functional traits:
Forms tight monolayers
Supports tube formation in angiogenesis assays
Responds to inflammatory cytokines (TNF-, IL-1)
-Growth behavior: Robust, stable proliferation compared to primary cells
Quick Facts
Product Type
Primary cells
Viability
>95% viable (Trypan Blue exclusion)
Applications
-Lung disease research Acute lung injury (ALI) …
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
-Lung disease research Acute lung injury (ALI) Acute respiratory distress syndrome (ARDS) Pulmonary hypertension -Drug discovery Screening vascular-targeted therapeutics -Inflammation studies Endothelial activation pathways (NF-B
Suitable for -lung disease research acute lung injury (ali) acute respiratory distress syndrome (ards) pulmonary hypertension -drug discovery screening vascular-targeted therapeutics -inflammation studies endothelial activation pathways (nf-b studies and research applications
MAPK) -Cancer research Tumor metastasis through the lung microvasculature -Barrier integrity assays TEER and permeability testing
Suitable for mapk) -cancer research tumor metastasis through the lung microvasculature -barrier integrity assays teer and permeability testing studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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