hTert Immortalized Human Retinal Microvascular Endothelial Cells
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Product Overview
Description
hTERT-Immortalized Human Retinal Microvascular Endothelial Cells (HRMVECs-hTERT) are a specialized cell line derived from primary human retinal microvascular endothelial cells (HRMVECs) through the ectopic expression of human telomerase reverse transcriptase (hTERT). These cells serve as a robust and reproducible in vitro model for studying the biology of the retinal microvasculature, the blood-retinal barrier, and related vascular diseases.
Guarantee expansion for a minimum of 2-5 population
doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBP0010-IChTert
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
CELLS CHARACTERIZATION
* Morphology: HRMVECs-hTERT appear morphologically similar to their primary endothelial cell counterparts, maintaining a normal cobblestone-like endothelial morphology in culture.
* Extended Lifespan: The cells exhibit high proliferative capacity, with confirmed telomerase activity and sustained growth well beyond the replicative senescence typical of primary cells.
* Genetic Stability: The immortalization process does not alter the genetic stability of the cells, preserving a diploid karyotype closely resembling that of primary HRMVECs.
* Endothelial Markers: The cells express characteristic endothelial surface markers, including CD31/PECAM-1, confirming their endothelial identity.
* Stem/Progenitor Markers: HRMVECs-hTERT also express the progenitor/stem cell marker nestin.
* Differentiation Potential: These cells retain the ability to differentiate into distinct phenotypes depending on growth factors and culture conditions, including neuronal phenotypes expressing MAP2 and glial phenotypes expressing GFAP.
* Colony Formation: The cells demonstrate high colony formation capacity and plating efficiency compared to primary cells.
Quick Facts
Product Type
Human Endothelial cells
Viability
>95% viable (Trypan Blue exclusion)
Applications
Research & Development
Availability
In Stock • Global Shipping
Technical Specifications
Applications & Use Cases
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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