Cre-Expressing Human Primary Bronchial Epithelial Cells
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Product Overview
Description
Cre-expressing Human Primary Bronchial Epithelial cells are a highly specialized and meticulously characterized cell line derived from human airway tissues. These cells are engineered to express Cre recombinase, an enzyme that facilitates site-specific recombination in DNA, enabling researchers to manipulate gene expression with precision. This unique feature makes them invaluable tools for studying the complex biology of the respiratory epithelium, including the interplay of genes during development, disease progression, and in response to therapeutic interventions.
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Key Features
Catalog Number: NBP-1987Cre
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
CELL CHARACTERISTICS
- Origin: Derived from human bronchial epithelium, mimicking the native cellular environment of the respiratory tract.
- Expression: Stably expresses Cre recombinase, allowing for precise genetic modifications driven by specific promoters.
- Morphology: Cells exhibit a typical columnar epithelial morphology, characterized by tight junctions and cilia, essential for respiratory function and clearance of mucus and pathogens.
- Growth Conditions: Requires specific cell culture media supplemented with necessary growth factors to maintain optimal viability and function. Recommended media includes bronchial epithelial cell growth supplements that provide the nutrients conducive for healthy cell proliferation.
Quick Facts
Product Type
Endothelial Cells (Cre-expressing)
Viability
>95% viable (Trypan Blue exclusion)
Applications
Gene Expression Studies: Investigate the effects …
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
Gene Expression Studies: Investigate the effects of specific gene alterations on airway cell function and behavior. - Drug Testing and Toxicity Assessments: Evaluate the efficacy and safety of new pharmaceuticals in a more physiologically relevant context
Suitable for gene expression studies: investigate the effects of specific gene alterations on airway cell function and behavior. - drug testing and toxicity assessments: evaluate the efficacy and safety of new pharmaceuticals in a more physiologically relevant context studies and research applications
reflecting human responses. - Investigating Lung Disease Mechanisms: Explore the underlying mechanisms of various respiratory conditions such as asthma
Suitable for reflecting human responses. - investigating lung disease mechanisms: explore the underlying mechanisms of various respiratory conditions such as asthma studies and research applications
COPD
Suitable for copd studies and research applications
and lung cancer by manipulating gene expression. - Regenerative Medicine and Tissue Engineering: Facilitate the development of innovative strategies for repairing or regenerating damaged lung tissue through advanced cellular therapies.
Suitable for and lung cancer by manipulating gene expression. - regenerative medicine and tissue engineering: facilitate the development of innovative strategies for repairing or regenerating damaged lung tissue through advanced cellular therapies. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
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