Human Brain Microvascular Pericytes
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Product Overview
Description
Human Brain Microvascular Pericytes are unique and specialized support cells that reside around the microcapillaries of the brain. These essential cells play a vital role in upholding the integrity of the blood-brain barrier, a critical protective shield that regulates the movement of substances between the bloodstream and the brain.
By supporting the stability of endothelial cells, which line the blood vessels, pericytes help maintain the proper structure and function of the vascular system in the brain. Additionally, they regulate vascular permeability, ensuring that only the appropriate molecules pass through to nourish brain tissue while keeping harmful substances at bay.
Through their contributions, pericytes are integral to the complex interplay of cells and systems that support neurovascular function, impacting overall brain health and activity.
Guarantee expansion for a minimum of 2-5 population doublings.
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Key Features
Catalog Number: NBP-0030
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Characteristics:
Human brain microvascular pericytes typically express pericyte-associated markers such as PDGFR-, NG2, CD146, Desmin, and -SMA. They exhibit spindle-shaped or stellate morphology in culture and interact closely with brain microvascular endothelial cells and astrocytes.
Quick Facts
Product Type
Human Endothelial cells
Viability
>90% viability post-thaw
Applications
These cells are commonly used for blood-brain bar…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
These cells are commonly used for blood-brain barrier research
Suitable for these cells are commonly used for blood-brain barrier research studies and research applications
neurovascular disease modeling
Suitable for neurovascular disease modeling studies and research applications
angiogenesis studies
Suitable for angiogenesis studies studies and research applications
drug permeability testing
Suitable for drug permeability testing studies and research applications
CNS toxicity screening
Suitable for cns toxicity screening studies and research applications
inflammation studies
Suitable for inflammation studies studies and research applications
and 3D brain vascular or BBB model development.
Suitable for and 3d brain vascular or bbb model development. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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