Conditionally Immortalized Human Umbilical Cord-Derived Mesenchymal Stem Cells
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Description
Conditionally Immortalized Human Umbilical Cord-Derived Mesenchymal Stem Cells (ciUC-MSCs), Catalog #CIHU001, are generated from primary human umbilical cord Wharton’s jelly-derived MSCs. The cells are genetically engineered via lentiviral transduction to express Simian Virus 40 Large T antigen (SV40 LT) under the control of a TetON inducible system.
In the presence of doxycycline (Dox), SV40 LT expression is activated, enabling reversible cell cycle immortalization. In the absence of Dox, SV40 LT expression is silenced, and cells return to a finite replication capacity. Following transduction, cells were selected with Puromycin to ensure stable integration of the transgene.
Morphologically, ciUC-MSCs exhibit characteristic spindle-shaped, fibroblast-like appearance and maintain typical mesenchymal stem cell surface marker expression.
Key Features
Catalog Number: CIHU001
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:2 (P2)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Quick Facts
Product Type
Stem Cells
Viability
>90% viable (Trypan Blue exclusion)
Applications
Research & Development
Availability
In Stock • Global Shipping
Technical Specifications
Applications & Use Cases
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
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