Human Primary Diabetic Aortic Smooth Muscle Cells
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Product Overview
Description
Human Primary Diabetic Aortic Smooth Muscle Cells are cryopreserved primary vascular smooth-muscle cells intended for in vitro studies of diabetes-associated cellular dysfunction, tissue remodeling, signaling, and pharmacology. Early-passage use is recommended to reduce phenotype drift and preserve application-relevant behavior.
Guarantee expansion for a minimum of 2-6 population
doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBPDS001
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Cell Characterization
Dysfunctional Metabolism: They often show altered glucose uptake and utilization, increased oxidative stress, and mitochondrial dysfunction.
Accelerated Senescence: Cells from diabetic donors tend to senesce (stop dividing) earlier in culture due to chronic high glucose exposure and oxidative damage.
Phenotypic Switching: Vascular SMCs are not terminally differentiated; they can switch between a contractile (quiescent) and a synthetic (proliferative/migratory) phenotype. Diabetic SMCs are often locked into a more "synthetic" or "pro-inflammatory" state.
Extracellular Matrix (ECM) Remodeling: They may produce abnormal amounts of ECM proteins (like collagen and fibronectin), contributing to vascular stiffness.
Calcification Potential: These cells have a heightened propensity to undergo osteogenic differentiation, leading to vascular calcification a major complication in diabetic patients.
Quick Facts
Product Type
Human Type II Diabetes Endothelial Cells
Viability
>95% viable (Trypan Blue exclusion)
Applications
-Atherosclerosis Studies: Investigating how high …
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
-Atherosclerosis Studies: Investigating how high glucose accelerates plaque formation and instability. -Vascular Calcification: Studying the mechanisms by which diabetes promotes the hardening of arteries. -Drug Screening: Testing novel anti-diabetic drugs or cardiovascular compounds to see how they affect diseased vs. healthy vasculature. -Mechanistic Pathways: Exploring specific pathways like PKC activation
Suitable for -atherosclerosis studies: investigating how high glucose accelerates plaque formation and instability. -vascular calcification: studying the mechanisms by which diabetes promotes the hardening of arteries. -drug screening: testing novel anti-diabetic drugs or cardiovascular compounds to see how they affect diseased vs. healthy vasculature. -mechanistic pathways: exploring specific pathways like pkc activation studies and research applications
advanced glycation end-products (AGEs) and their receptor (RAGE)
Suitable for advanced glycation end-products (ages) and their receptor (rage) studies and research applications
inflammation
Suitable for inflammation studies and research applications
and insulin resistance in vascular tissue.
Suitable for and insulin resistance in vascular tissue. studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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