Human Brain Microvascular Endothelial Cells Expressing GFP-AEQ in Mitochondria
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Product Overview
Description
Human Brain Microvascular Endothelial Cells engineered to express GFP-tagged aequorin targeted to mitochondria are a specialized model used to study endothelial function and mitochondrial calcium signaling within the blood–brain barrier (BBB). These cells combine the physiological relevance of brain microvascular endothelium with real-time fluorescent and bioluminescent reporting tools.
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Key Features
Catalog Number: NBP-0002AEQ-GFP-mito
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
CELL CHARACTERISTICS
-Brain microvascular origin with BBB-like properties
-Tight junction formation capability (e.g., claudins, occludin expression)
-GFP-labeled mitochondria for live-cell imaging of mitochondrial distribution and morphology
-Aequorin-based calcium sensing allows detection of mitochondrial Ca² flux in real time
-High metabolic activity, reflecting the energy demand of BBB endothelial cells
-Suitable for fluorescence and luminescence dual-mode imaging
Quick Facts
Product Type
GFP Expressing AEQ Cells
Viability
>85% viable (Post-thaw)
Applications
-Blood–Brain Barrier Research Transport regulati…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
-Blood–Brain Barrier Research Transport regulation Barrier integrity studies -Mitochondrial calcium signaling Neurovascular coupling mechanisms Cellular stress response pathways -Neurodegenerative disease modeling Alzheimer’s
Suitable for -blood–brain barrier research transport regulation barrier integrity studies -mitochondrial calcium signaling neurovascular coupling mechanisms cellular stress response pathways -neurodegenerative disease modeling alzheimer’s studies and research applications
Parkinson’s
Suitable for parkinson’s studies and research applications
stroke-related endothelial dysfunction -Drug screening BBB permeability testing Neurovascular-targeted therapeutics -Live-cell imaging studies Mitochondrial dynamics (fission/fusion) Reactive oxygen species (ROS)-linked pathways
Suitable for stroke-related endothelial dysfunction -drug screening bbb permeability testing neurovascular-targeted therapeutics -live-cell imaging studies mitochondrial dynamics (fission/fusion) reactive oxygen species (ros)-linked pathways studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
Technical Support
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