Human Retinal Microvascular Pericytes Expressing GFP-AEQ in Mitochondria
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Product Overview
Description
Human Retinal Microvascular Pericytes, carefully engineered to express a GFP-aequorin biosensor localized to mitochondria, serve as specialized support cells within the retinal vascular network. These unique pericytes play a crucial role in maintaining the health and integrity of retinal blood vessels. As a result of their innovative design, they are invaluable for investigating a wide range of important physiological and pathological processes.
Researchers can utilize these cells to explore mitochondrial calcium signaling, which is essential for cellular function, as well as to study the intricate workings of the retinal microvascular system. Additionally, they provide insights into the functioning of the blood-retinal barrier, the impact of oxidative stress on retinal health, the processes involved in vascular remodeling, and the underlying mechanisms associated with diabetic retinopathy. This comprehensive understanding is fundamental to developing potential therapeutic interventions for retinal diseases.
Guarantee expansion for a minimum of 2-5 population doublings.
IMPORTANT: Quality warranty requires use of NeoBioPharma media. Biohazardous material despite negative pathogen testing. Quality claims must be reported within 1 month.
Key Features
Catalog Number: NBP-0025AEQ-GFP-Mito
Product Format: Frozen
Vial Cell Number: > 5x10[5] cells/vial
Passage:1(P1)
Storage: Liquid Nitrogen, Vapor Phase
Intended Use: Research use only (RUO)
Characteristics:
-Human retinal microvascular pericyte phenotype
-GFP-AEQ signal localized to mitochondria
-Suitable for mitochondrial calcium imaging and functional assays
-Supports studies of retinal capillary stability and pericyte-endothelial interaction
-Cryopreserved for recovery and expansion in culture
-Recommended for retinal vascular disease, neurovascular, and drug screening research
Quick Facts
Product Type
Human Endothelial cells
Viability
>90% viability post-thaw
Applications
-Mitochondrial calcium signaling studies -Diabet…
Availability
In Stock • Global Shipping
Technical Specifications
Primary Applications
Applications & Use Cases
Primary Applications
-Mitochondrial calcium signaling studies -Diabetic retinopathy research -Blood-retinal barrier models -Retinal vascular dysfunction studies -Oxidative stress and mitochondrial toxicity assays -Co-culture with retinal endothelial cells -Drug discovery and vascular protection screening
Suitable for -mitochondrial calcium signaling studies -diabetic retinopathy research -blood-retinal barrier models -retinal vascular dysfunction studies -oxidative stress and mitochondrial toxicity assays -co-culture with retinal endothelial cells -drug discovery and vascular protection screening studies and research applications
Research Areas
In Vitro Studies
Cell culture and screening applications
Molecular Biology
Gene expression & signaling studies
Drug Discovery
Screening & validation studies
Disease Modeling
Pathophysiology research
Support & Resources
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